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D Hamlin1, K Phelan Williams1, E Delgado2, YP Zhang2, W DeVizio2, LR Mateo3
A Clinical Investigation of the Efficacy of a Desensitizing Paste Containing 8 % Arginine and Calcium Carbonate for the Reduction of Dentin Hypersensitivity When Applied Prior to Dental Prophylaxis
In: American Journal of Dentistry 2009, 22 (Spec Iss A): 16A – 20A
- 1Contract Dental Evaluations, Langhorn, PA
- 2Colgate-Palmolive Technology Center, Piscataway, NJ
- 3LRM Consulting, Hoboken, NJ
The objective of the study was to compare the efficacy in reducing dentine hypersensitivity of two in-office pastes when applied as a preprocedure to a professional dental cleaning.
Trial Conditions and Methods
Products Under Investigation
Test: Colgate® Sensitive Pro-Relief™ desensitising paste (Colgate Palmolive, New York, NY) containing 8 % arginine in a calcium carbonate/silica base.
Control: Nupro pumice-based fluoride free prophylaxis paste (Dentsply, York, PA)
A total of 45 male and female subjects (aged between 23 and 66 years) with established dentine hypersensitivity (two hypersensitive teeth with a tactile sensitivity score [Yeaple probe] of 10 – 50 grams of force and an air blast score of 2 or 3 on the Schiff Cold Air Sensitivity Scale).
In this double-blind, parallel group study, 45 subjects with established dentine hypersensitivity were randomly assigned to either the test (n = 22) or control (n = 23) group. Following baseline evaluation of dentine hypersensitivity, the assigned in-office paste was applied as a pre-procedural step prior to professional cleaning. Immediately after completion of the cleaning procedure, subjects were re-evaluated for tactile and air blast sensitivity scores. Statistical analyses were performed separately for tactile and air blast scores. Within treatment comparisons were performed using a t-test. Comparisons between treatments using baseline adjusted scores were performed using analysis of covariance (ANCOVA).
Immediately after the cleaning procedure, subjects assigned to the test product demonstrated statistically significant improvements from baseline in tactile (132.1 %) and air blast (48.6 %) sensitivity scores. At the same time point, subjects assigned to the control product demonstrated statistically significant improvements from baseline in air blast (13.9 %) sensitivity score. The improvement from baseline in tactile sensitivity score (21.7 %) in the control subjects was not statistically significant.
Immediately after the cleaning procedure, the test product group demonstrated statistically significant improvements compared to the control group in tactile (110.0 %) and air blast (41.9 %) sensitivity scores.
When applied prior to a professional dental cleaning, Colgate® Sensitive Pro-Relief™ desensitising paste with 8 % arginine and calcium carbonate provides a statistically significant reduction in dentine hypersensitivity measured immediately following the dental cleaning as compared to a control prophylaxis paste.