The Journal of Clinical Dentistry®, Colgate Total Supplement

Download Printable Version

2014, Volume XXV, Supplement

Advanced Oral Antibacterial/Anti-inflammatory Technology: A Comprehensive Review of the Benefits of a Triclosan/Copolymer/Fluoride Dentifrice

Fotinos S. Panagakos, DMD, PhD Anthony R. Volpe, DDS, MS
Margaret Petrone, JD Boyce M. Morrison, Jr, PhD William DeVizio, DMD
Colgate-Palmolive Technology Center
Piscataway, NJ, USA
Howard M. Proskin, PhD
Howard M. Proskin and Associates
Rochester, NY, USA


Triclosan is a broad-spectrum antibacterial agent, marketed for use in oral care products; it is effective against both Gram-positive and Gram-negative bacteria. PVM/MA is the non-proprietary designation for a polyvinylmethyl ether maleic acid copolymer. It has been demonstrated that there is a greater uptake of triclosan to enamel and buccal epithelial cells from the use of a fluoride dentifrice containing triclosan and the PVM/MA copolymer than from a dentifrice containing triclosan alone. This Supplement to The Journal of Clinical Dentistry reviews the published literature, which reports the laboratory and clinical studies that have been conducted on a triclosan/copolymer/fluoride dentifrice in a variety of oral health conditions.

The laboratory and clinical studies reviewed within this Supplement clearly indicate that the use of a triclosan/copolymer/fluoride dentifrice (Colgate® Total® Toothpaste, Colgate-Palmolive Company, New York, NY, USA) provides oral health benefits beyond those associated with a "traditional" dentifrice, in a manner that is safe and effective. These demonstrate that Colgate Total Toothpaste provides superior protection against plaque and gingivitis, calculus, caries, oral malodor, and peri-implant mucositis. Colgate Total Toothpaste also provides superior whitening and stain removal benefits. It also provides protection against the progression of periodontal disease. In addition, a specific variant of Colgate Total Toothpaste provides dentin hypersensitivity benefits. Colgate Total Toothpaste has been proven to provide superior oral health benefits to a dentifrice containing stannous fluoride, sodium hexametaphosphate and zinc lactate. Finally, these studies provide the necessary scientific support so that dental professionals can recommend Colgate Total Toothpaste to their patients for use as part of their overall oral hygiene regimen.

(J Clin Dent 2014;25(Suppl):S1-30)

To read or print the whole article, please download the PDF using the link provided.