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Arginine is an amino acid that is found naturally in saliva. When formulated correctly into oral care products, arginine is capable of plugging and sealing open dentin tubules, thereby providing relief from dentin hypersensitivity (Pro-Argin™ technology). The Colgate-Palmolive Company has used advanced science and technology to achieve immediate, as well as lasting relief from dentin hypersensitivity through the development of arginine-based in-office pastes, dentifrices, and oral rinses, all based on this Pro-Argin technology. This Supplement to The Journal of Clinical Dentistry reviews the published literature, which reports the laboratory and clinical studies that have been conducted on arginine-based oral care products.